Single-cell datasets are growing in size, posing challenges as well as opportunities to biology researchers. ondisc (short for “on-disk single cell”) is an R package that facilitates computing on large-scale single-cell data. ondisc is especially well-suited to fixed memory and distributed CRISPR screen and differential expression analyses.

NOTE: The package currently is undergoing considerable API changes. Use with caution. We anticipate that an updated, stable version of the package (along with detailed documentation) will be available in September, 2021.


You can install the package from CRAN with:

You can install the development version from Github with: