May 2, 2024

Tim Barry

Genomics

An overview of genome-wide association studies.

Jan. 19, 2023

Tim Barry

Statistics

A dive into the theory behind GLMs. This post covers the GLM model, canonical and non-canonical link functions, optimization of the log-likelihood, and inference.

Aug. 15, 2022

Tim Barry

Genomics

We overview single-cell RNA sequencing, at both small and large scales.

Aug. 11, 2020

Tim Barry

Genomics

DNA sequencing lies at the core of modern genomic assays. Here, we discuss next-generation sequencing and the related technology of polymerase chain reaction.

July 12, 2020

Tim Barry

Statistics

The exponential family is a mathematical abstraction that unifies common parametric probability distributions. In this post we review the definition and basic properties of exponential families.

June 16, 2020

Tim Barry

Statistics

The gamma, Poisson, and negative binomial distributions are used extensively in genomics. In this post we review these distributions and their connections to one another. We also cover the various (and somewhat confusing) parameterizations of these distributions.

May 27, 2020

Tim Barry

Genomics

Enhancers are segments of DNA that increase the expression of a nearby gene. This post provides an overview enhancer biology and detection of enhancers at scale.

- Articles (7)
- Genomics (4)
- Statistics (3)